
产品货号:
Z16783
中文名称:
ERBB3抗体
英文名称:
Anti-ERBB3 Antibody
产品规格:
250μg
发货周期:
1~3天
产品价格:
询价
抗体名称 | Anti-ERBB3 Antibody |
指标别名 | c erbB 3;c erbB3;ErbB 3;ERBB3;erbB3 S;HER3;LCCS2;MDA BF 1;p180 ErbB3;p45 sErbB3;p85 sErbB3 |
克隆性 | Polyclonal |
检验物种 | human |
应用范围 | ELISA,IP,WB |
基因名称 | ERBB3 |
抗体来源 | Rabbit |
抗体类型 | IgG |
免疫原 | Anti-HER3 whole rabbit serum was prepared by repeated immunizations with a HER3 fusion protein corresponding to amino acids 1283 to 1323 (40 amino acids) at the carboxy-terminus of human HER3. |
成分 | 0.02M Potassium Phosphate,0.15M Sodium Chloride,pH7.2,0.01% (w/v) Sodium Azide |
纯化方式 | Rabbit Anti-HER3 is an IgG fraction antibody purified from monospecific antiserum by Protein A chromatography followed by cross adsorption against GST and extensive dialysis against the buffer stated above.Assay by immunoelectrophoresis resulted in a single precipitin arc against anti-Rabbit Serum.The antibody is directed against human HER3 and is useful in determining its presence in immunoprecipitation experiments.This antibody can detect HER3 from human,mouse and rat sources.?Reactivity of this antibody with HER3 from other species is unknown. |
浓度 | 2.5mg/mL by UV absorbance at 280nm |
产品形态 | 溶液 |
保存条件 | Store Anti-HER3 at -20℃ prior to opening.Aliquot contents and freeze at -20℃ or below for extended storage.Avoid cycles of freezing and thawing.Centrifuge product if not completely clear after standing at room temperature.This product is stable for several weeks at 4℃ as an undiluted liquid.Dilute only prior to immediate use.Expiration date is one (1) year from date of opening. |
背景资料 | HER3 antibody is ideal for western blotting,ELISA and IP.The human Epidermal Growth Factor Receptor (EGFR) family is a family of receptor tyrosine kinases consisting of 4 members:EGFR,HER2,HER3 and HER4.These receptors are expressed on a wide variety of tissue types and have been implicated in many human cancers,including breast,gastric,colon and prostate.Strong expression of both HER3 and HER2 (also known as p185neu) by tumor cells can be associated with poor outcome for patients.The ligand for HER3 and HER4 is called Neu Differentiation Factor (NDF) or Heregulin.In some instances,antibodies against these receptors prove effective in combination therapy regimens for treatment of the disease.Signaling through the EGFR family involves the combinatorial dimerization of the four known family members and is mediated by at least 8 different hormones,including EGF and the heregulins.Heregulin binding and tyrosine phosphorylation by HER3 or HER4 is enhanced in the presence of HER2.Structurally the members of the EGFR family are 1210 to 1342 amino acids in length with approximately 650 amino acids of the extracellular domain being heavily glycosylated.The extracellular domains show up to 70% sequence homology. |
Uniprot ID | P21860 |
推荐稀释比 | ELISA:1:10,000 - 1:50,000 IP:Use 5μL antibody. WB:1:500- 1:2,000 |
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